李昂：教授，博士生导师
E-mail：angli41@sdu.edu.cn
教育背景
2013.09-2019.06 博士 中国科学院北京基因组研究所 生物化学与分子生物学
2009.09-2013.06 学士 鲁东大学 生物工程
工作经历
2022.10-至今 山东大学 教授 齐鲁青年学者（第一层次）
2019.07-2022.07 普林斯顿大学 博士后
研究方向和成果
研究主要集中于发现新的RNA修饰的修饰酶及其结合蛋白、探究RNA修饰的分布规律以及揭示RNA修饰在调控RNA命运决定和生理及病理中的作用。目前已发表研究论文13篇，总引用次数约4500余次，其中近五年来，研究成果以第一作者（含共同）发表在Nature Communications（2022），ACS Chemical Biology（2022），Nature Chemical Biology（2021）, Cell Research（2019，2017）, Nature Cell Biology（2019）杂志上。曾获得中科院院长优秀奖和朱李月华优秀博士生奖学金等奖项。本研究组综合利用生物化学与分子生物学、生物信息学和化学生物学等研究方法揭示RNA在生命活动中的调控作用。本课题组长期招聘博士后，欢迎对RNA生物学感兴趣的同学报考硕士和博士。
具体研究内容包括：
1.开发单位点水平检测RNA修饰的方法。
2.鉴定RNA修饰酶及结合蛋白并研究其生物学功能。
研究成果
(* Co-first-author equivalent, # Corresponding-author equivalent):
1. A. Emilia Arguello*, Ang Li*, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer & Ralph E. Kleiner# Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases. Nature Communications 13, 4176 (2022).
2. Ang Li, Xuemeng Sun, A. Emilia Arguello, & Ralph E. Kleiner# Chemical method to sequence 5-formylcytosine on RNA. ACS Chemical Biology 2022, 17, 3, 503–508
3. Wei Dai*, Ang Li*, Nathan J. Yu, Thao Nguyen, Robert W. Leach, Martin Wühr & Ralph E. Kleiner# Activity-based RNA modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Nature Chemical Biology 2021, 17, pages1178–1187
4. Xin Chen*, Ang Li*, Bao-Fa Sun*,Ying Yang*, Ya-Nan Han*, Xun Yuan*, Ri-Xin Chen, Wen-Su Wei, Yanchao Liu, Chun-Chun Gao, Yu-Sheng Chen, Mengmeng Zhang, Xiao-Dan Ma, Zhuo-Wei Liu, Jun-Hang Luo, Jinbiao Ma, Cong Lyu, Hai-Lin Wang, Jinbiao Ma, Yong-Liang Zhao, Fang-Jian Zhou, Ying Huang#, Dan Xie#, Yun-Gui Yang#. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nature Cell Biology 21, 978–990 (2019)
5. Rong Wu*, Ang Li*, Baofa Sun*, Jian-Guang Sun*, Jinhua Zhang*, Ting Zhang*, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao,Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang#, Yun-Gui Yang#, Zengqiang Yuan #. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research (2019) 0:1–19
6. Ang Li*, Yu-Sheng Chen*, Xiao-Li Ping, Xin Yang, Wen Xiao, Ying Yang, Hui-Ying Sun, Qin Zhu, Poonam Baidya, Xing Wang, Devi Prasad Bhattarai, Yong-Liang Zhao, Bao-Fa Sun# and Yun-Gui Yang#. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation. Cell Research 3：444-447 (2017)
7. Ying Yang *, Lu Wang *, Xiao Han *,Wen-Lan Yang*, Mengmeng Zhang, Hai-Li Ma, Bao-Fa Sun, Ang Li, Jun Xia, Jing Chen, Jian Heng, Baixing Wu, Yu-Sheng Chen, Jia-Wei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hai-Lin Wang, Ying Huang, Ying-Pu Sun, Yong-Liang Zhao, Anming Meng, Jinbiao Ma, Feng Liu#, Yun-Gui Yang# RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell 2019, 75 (6), 1188-1202.e11 2019 Sep 19
8. Chen-Xin Wang*, Guan-Shen Cui *, Xiuying Liu* , Kai Xu *, Meng Wang* , Xin-Xin Zhang, Li-Yuan Jiang, Ang Li, Ying Yang, Wei-Yi Lai, Bao-Fa Sun, Gui-Bin Jiang, Hai-Lin Wang, Wei-Min Tong, Wei Li, Xiu-Jie Wang #, Yun-Gui Yang# , Qi Zhou#. METTL3-mediated m6A modification is required for cerebellar development. PLoS Biol 2018 Jun 7.
9. Xin Yang*, Ying Yang*, Bao-Fa Sun*, Yu-Sheng Chen*, Jia-Wei Xu*, Wei-Yi Lai*, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chun-Min Huang, Niu Huang, Gui-Bin Jiang, Yong-Liang Zhao, Hai-Lin Wang#, Ying-Pu Sun#, Yun-Gui Yang#. 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader. Cell Research 27:606–625 (2017);
10. Wen Xiao*, Samir Adhikari*, Ujwal Dahal*, Yu-Sheng Chen*, Ya-Juan Hao*, Bao-Fa Sun*, Hui-Ying Sun, Ang Li, Xiao-Li Ping, Wei-Yi Lai, Xing Wang, Hai-Li Ma, Chun-Ming Huang, Ying Yang, Niu Huang, Gui-Bin Jiang, Hai-Lin Wang, Qi Zhou, Xiu-Jie Wang, Yong-Liang Zhao, Yun-Gui Yang#. Nuclear m6A readerYTHDC1 regulates mRNA splicing Molecular Cell 61 (4): 507-519 (2016);
11. Tong Chen*, Ya-Juan Hao*, Ying Zhang*, Miao-Miao Li*, Meng Wang, Weifang Han, Yongsheng Wu, Ying Lv, JieHao, Libin Wang, Ang Li, Ying Yang, Kang-Xuan Jin, Xu Zhao, Yuhuan Li, Xiao-Li Ping, Wei-Yi Lai, Li-Gang Wu, Guibin Jiang, Hai-Lin Wang, Lisi Sang, Xiu-Jie Wang#, Yun-Gui Yang#, and Qi Zhou#. m6A RNA methylation is regulated by micrornas and promotes reprogramming to pluripotency. Cell Stem Cell; 16(3):1-13 (2015)
12. Xiao-Li Ping*, Bao-Fa Sun*, Lu Wang*, Wen Xiao*, Xin Yang, Wen-Jia Wang, Samir Adhikari, Yue Shi, Ying Lv, Yu-Sheng Chen, Xu Zhao, Ang Li, Ying Yang, Ujwal Dahal, Xiao-Min Lou, Xi Liu, Jun Huang, Wei-Ping Yuan, Xiao-Fan Zhu, Tao Cheng, Yong-Liang Zhao, Xinquan Wang, Jannie M Rendtlew Danielsen, Feng Liu#, Yun-Gui Yang#. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Research 24(2):177–189 (2014)
13. Dongfang Xie*, Man Tong*, Baolong Xia*, Guihai Feng*, Leyun Wang*, Ang Li, Guanzheng Luo, Haifeng Wan, Zeyu Zhang, Hao Zhang, Yun-Gui Yang, Qi Zhou#, Meng Wang#, Xiu-Jie Wang#. Long noncoding RNA lnc-NAP sponges mmu-miR-139-5p to modulate Nanog functions in mouse ESCs and embryos. RNA Biology, 2020 doi: 10.1080/15476286.2020.1827591
