李双喜 研究员

E-Mail：shuangxi@sdu.edu.cn

Background:

2021.3-  1929cc威尼斯(中国)有限公司   研究员  

2019.1-2021.2  斯坦福大学医学院 Basic Life Research Scientist

2016.12-2018.12  斯坦福大学医学院   Postdoc

2014.7-2016.11  德州大学西南医学中心(UTSW) Postdoc

2011.7-2014.6 德州大学西南医学中心(UTSW) 联合培养

2007.9-2013.11  华东师范大学1929cc威尼斯   博士

Research interests:

1. Molecular mechanisms of neurodegenerative diseases

2. Ribosome-associated quality control (RQC)

Funding:

2021-2026，神经退行性疾病的分子机制研究，山东大学“齐鲁青年学者”建设经费。

Join us:

本实验室长期招收博士后、博士和硕士研究生，欢迎加入！

Publications:

1)Shuangxi Li, Zhihao Wu, Ishaq Tantray, Yu Li, Songjie Chen, Jason Dong, Steven Glynn, Hannes Vogel, Michael Snyder, and Bingwei Lu. Quality control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Proc Natl Acad Sci. 2020 Sep 21;202005506

2) Shuangxi Li^#, Zhihao Wu^#, Yu Li, Ishaq Tantray, Diego De Stefani, Andrea Mattarei, Fen-Biao Gao, Hannes Vogel, and Bingwei Lu. Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Cell Reports. 2020 Aug 4; 32(5):107989

3) Shuangxi Li^#, Aiguo Tian^#, Shuang Li^#, Yuhong Han, Bing Wang, Jin Jiang. Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut. J Cell Biol. 2020 Apr 6; 219 (4).

4) Shuangxi Li^#, Shuang Li^#, Yuhong Han, Chao Tong, Bing Wang, Yongbin Chen, Jin Jiang. Regulation of Smo phosphorylation and high-level Hh signaling activity by a plasma membrane associated kinase. PLoS Biol. 2016 Jun 9;14(6)

5) Shuangxi Li^#, Yong Suk Cho^#,Tao Yue, Y Tony Ip, Jin Jiang. Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling. Cell Discov. 2015 Nov 24;1:15038

6) Shuangxi Li^#, Cong Jiang^#, Jingjing Pan, Xinbo Wang, Jiali Jin, Linlin Zhao, Weijuan Pan, Guanghong Liao, Xin Cai, Xiaotao Li, Jianru Xiao, Jin Jiang, Ping Wang. Regulation of c-Myc protein stability by proteasome activator REGgamma. Cell Death Differ. 2015 Jun;22(6):1000-11

7) Qi Li, Shuangxi Li, Sebastian Mana-Capelli, Rachel J. Roth Flach, Laura V. Danai, Alla Amcheslavsky, Yingchao Nie, Satoshi Kaneko, Xiaohao Yao, Xiaochu Chen, Jennifer L. Cotton, Junhao Mao, Dannel McCollum, Jin Jiang, Michael P. Czech, Lan Xu and Y. Tony Ip. The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell (2014) Nov 10;31(3):291-304

8) Zoe H Davis, Laura Mediani, Francesco Antoniani, Jonathan Vinet, Shuangxi Li, Simon Alberti, Bingwei Lu, Alex S Holehouse, Serena Carra, Onn Brandman. Protein products of nonstop mRNA disrupt nucleolar homeostasis. Cell Stress Chaperones. 2021 Feb 22.

9) Shuang Li, Shuangxi Li, Bing Wang, Jin Jiang. Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases. Sci Signal. 2018 Feb 6;11(516).

10)Qing Shi, Shuang Li, Shuangxi Li, Alice Jiang, Yongbin Chen, Jin Jiang. Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci. 2014 Dec 30;111(52):E5651-60

11) Shuang Li, Yong Suk Cho, Bing Wang, Shuangxi Li, Jin Jiang. Regulation of Smoothened Ubiquitylation and Cell Surface Expression Through a Cul4-DDB1-Gβ E3 Ubiquitin Ligase Complex. J Cell Sci. 2018 Aug 1;131(15)

12) Yong Suk Cho, Jian Zhu, Shuangxi Li, Bing Wang, Yuhong Han, Jin Jiang. Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K. Nat Commun. 2018 Apr 25;9(1):1657

13) Guoqiang Ma, Shuang Li, Yuhong Han, Shuangxi Li, Tao Yue, Bing Wang, Jin Jiang. Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway. Dev Cell. 2016 Nov 21;39(4):438-451.

14) Aiguo Tian, Qing Shi, Alice Jiang, Shuangxi Li, Bing Wang, and Jin Jiang. Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. J Cell Biol. 2015 Mar 16;208(6):807-19

15) Jinxia Sun, Yi Luan, Dong Xiang, Xiao Tan, Hui Chen, Qi Deng, Jiaojiao Zhang, Minghui Chen, Hongjun Huang, Weichao Wang, Tingting Niu, Wenjie Li, Hu Peng, Shuangxi Li, Lei Li, Wenwen Tang, Xiaotao Li, Dianqing Wu, Ping Wang. The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense Against Bacterial Pathogens. Cell Rep. 2016 Feb 2;14(4):737-749.

16) Ning Liu, Hui Li, Shuangxi Li, Mingyue Shen, Ning Xiao, Yunfei Chen, Yan Wang, Weichao Wang, Rui Wang, Qian Wang, Jianhua Sun, Ping Wang. The Fbw7/human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation Through Multiple Phosphodegron Motifs. J Biol Chem. 2010 Jun 11;285(24):18858-67.