汪正品：博士，研究员，博士/硕士生导师，山东大学“齐鲁青年学者”
E-mail：zhengpin.wang@sdu.edu.cn
教育背景
2008.09-2014.06 中国农业大学 生物学院 理学博士
2004.09-2008.06 华中农业大学 水产学院 农学学士
工作经历
2021.09-至今 山东大学 1929cc威尼斯 研究员
2015.02-2021.07 NIDDK 美国国立卫生研究院（NIH） 博士后
研究方向和成果
长期从事哺乳动物配子发生发育的相关研究工作，目前以第一作者/通讯作者身份在Nature Communications，Nucleic Acids Research，Journal of Biological Chemistry等杂志发表多篇生殖领域研究论文。应邀担任The FASEB Journal，Journal of Urology，Scientific Reports，Archives of Virology等杂志审稿人。曾荣获NIH Nancy Nossal Fellowship Award，NIH Fellows Award for Research Excellence (FARE)等奖励。实验室主要通过基因编辑技术构建小鼠模型，结合细胞生物学、发育生物学、生物化学及生物信息学等手段，研究遗传因素在配子发生发育过程中的分子调控机制。
具体研究内容包括：
1.生殖细胞转录因子复合体在早期卵母细胞生长和分化中的作用与机制
2.PRAME家族在精子发生与雄性不育中的作用与机制
3.核糖核酸酶在精子发生与雄性不育中的作用与机制
主持课题
2021.10-2026.10 精子发生与雄性不育的分子机制研究 山东大学“齐鲁青年学者”建设经费
代表性论文（*为通讯作者）
1.Zhengpin Wang; Xiaojiang Xu*; scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells, Cells, 2020, 9(4): 920.
2.Zhengpin Wang*; Chen-Yu Liu; Yangu Zhao; Jurrien Dean*; FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation, Nucleic Acids Research, 2020, 48(7): 3525-3541.
3.Zhengpin Wang*; Xiaojiang Xu; Jian-Liang Li; Cameron Palmer; Dragan Maric; Jurrien Dean*; Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice, Nature Communications, 2019, 10(1): 1-18.
4.Zhengpin Wang; Wanbao Niu; Yijing Wang; Zhen Teng; Jia Wen; Guoliang Xia; Chao Wang*; Follistatin288 regulates germ cell cyst breakdown and primordial follicle assembly in the mouse ovary, PLOS ONE, 2015, 10(6): e0129643.
5.Zhengpin Wang; Xinyi Mu; Meng Guo; Yijing Wang; Zhen Teng; Guanping Mao; Wanbao Niu; Lizhao Feng; Lihua Zhao; Guoliang Xia*; Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovary, Journal of Biological Chemistry, 2014, 289(12): 8299-8311.
6.Heejin Choi*; Zhengpin Wang; Jurrien Dean*; Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNA, PLOS Genetics, 2021, 17(4): e1009485.
7.Xinyi Mu; Jia Wen; Qian Chen; Zhengpin Wang; Yijing Wang; Meng Guo; Yi Yang; JinRui Xu; Zhiqing Wei; Guoliang Xia; Mengye Yang; Chao Wang*; Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice, Biology Open, 2018, 7(11): bio035626.
8.Meng Guo; Cheng Zhang; Yan Wang; Lizhao Feng; Zhengpin Wang; Wanbo Niu; Xiaoyan Du; Wang Tang; Yuna Li; Chao Wang*; Zhenwen Chen*; Progesterone receptor membrane component 1 mediates progesterone-induced suppression of oocyte meiotic prophase I and primordial folliculogenesis, Scientific Reports, 2016, 6(1): 1-14.
9.Wanbao Niu; Ye Wang; Zhengpin Wang; Qiliang Xin; Yijing Wang; Lizhao Feng; Lihua Zhao; Jia Wen; Hua Zhang; Chao Wang; Guoliang Xia*; JNK signaling regulates E-cadherin junctions in germline cysts and determines primordial follicle formation in mice, Development, 2016, 143(10): 1778-1787.
10.Yijing Wang; Zhen Teng; Ge Li; Xinyi Mu; Zhengpin Wang; Lizhao Feng; Wanbao Niu; Kun Huang; Xi Xiang; Chao Wang; Hua Zhang*; Guoliang Xia*; Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary, Development, 2015, 142(2): 343-351.
11.Cheng Zhang*; Xiaoxia Wang; Zhengpin Wang; Wanbao Niu; Baochang Zhu; Guoliang Xia*; Effect of different culture systems and 3, 5, 3'-triiodothyronine/follicle-stimulating hormone on preantral follicle development in mice, PLOS ONE, 2013, 8(4): e61947.
12.Xinyi Mu; Jing Wen; Meng Guo; Jianwei Wang; Ge Li; Zhengpin Wang; Yijing Wang; Zhen Teng; Yan Cui; Guoliang Xia*; Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells, Journal of Cellular Physiology, 2013, 228(3): 627-639.
13.Cheng Zhang; Wanbao Niu; Zhengpin Wang; Xiaoxia Wang*; Guoliang Xia*; The effect of gonadotropin on glucose transport and apoptosis in rat ovary, PLOS ONE, 2012, 7(8): e42406.
本课题组长期招聘博士后，欢迎对发育与生殖生物学感兴趣的同学报考硕士和博士。
